Starts 17 Nov 2020 15:00
Ends 17 Nov 2020 17:00
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What are we measuring with magnetic resonance spectroscopy: A neural field model of GABA/Glu synaptic transmission
Zoom meeting
https://zoom.us/j/475819702
Meeting ID: 475-819-702
If you haven't registered for previous QLS webinars, please contact qls@ictp.it to obtain the PASSWORD for this zoom meeting.
Abstract: Long-term changes to synaptic plasticity due to transcranial direct current stimulation (tDCS) have been linked to the dynamics of glutamate and GABA via the quantification of the neurotransmitter’s concentration from 1H-NMR spectroscopy (MRS) in vivo in a single scan session. However, our understanding of precisely which physiological processes underlie changes to GABA/Glu concentrations in response to stimulation remains unclear. In other words, what are we measuring with MRS in these situations? One theory is that we are measuring compartmental shifts of neurotransmitters from pre-synaptic vesicles to more visible synaptic, extracellular and cytosolic pools. It is important to understand because there are currently various therapeutic techniques used to target and modulate neurochemical distributions with the aim of promoting functional recovery (from stroke, for example). In this talk, I present the development of a neural model that incorporates neurotransmitter dynamics and calcium-dependent plasticity to allow us to probe the relationship between stimulation, neurotransmitter activity, and plasticity. I simulate tDCS to drive fluctuations in the model, and in so doing I demonstrate how tDCS modifies plasticity as well as the similarities between the model prediction and empirical MRS data. This modelling approach will allow mechanistically informed optimization of current stimulation parameters.
Meeting ID: 475-819-702
If you haven't registered for previous QLS webinars, please contact qls@ictp.it to obtain the PASSWORD for this zoom meeting.
Abstract: Long-term changes to synaptic plasticity due to transcranial direct current stimulation (tDCS) have been linked to the dynamics of glutamate and GABA via the quantification of the neurotransmitter’s concentration from 1H-NMR spectroscopy (MRS) in vivo in a single scan session. However, our understanding of precisely which physiological processes underlie changes to GABA/Glu concentrations in response to stimulation remains unclear. In other words, what are we measuring with MRS in these situations? One theory is that we are measuring compartmental shifts of neurotransmitters from pre-synaptic vesicles to more visible synaptic, extracellular and cytosolic pools. It is important to understand because there are currently various therapeutic techniques used to target and modulate neurochemical distributions with the aim of promoting functional recovery (from stroke, for example). In this talk, I present the development of a neural model that incorporates neurotransmitter dynamics and calcium-dependent plasticity to allow us to probe the relationship between stimulation, neurotransmitter activity, and plasticity. I simulate tDCS to drive fluctuations in the model, and in so doing I demonstrate how tDCS modifies plasticity as well as the similarities between the model prediction and empirical MRS data. This modelling approach will allow mechanistically informed optimization of current stimulation parameters.