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Description
Life is a nonequilibrium phenomenon, requiring the constant consumption of energy to circumvent the pernicious effects of fluctuations. Recent advances in experimental techniques and in the theory of nonequilibrium processes offer new opportunities for the study of fluctuations in biological systems.  

What are the energetic costs of key processes needed to sustain life at the cellular level? What statistical features are unique in biological systems? How can we harvest energy efficiently from living matter? What is the biological relevance of fundamental results such as the fluctuation theorems and the thermodynamic uncertainty relation?  

This workshop aims at gathering active scientists (experimentalists and theorists) from different domains across physics and biology who have made significant contributions to address fluctuations in living systems. The workshop will provide a unique framework for researchers from developing countries to establish a scientific dialogue with their counterparts from around the world performing cutting-edge research in physics and biology. Students and early career scientists will get a flavour of the possibilities and outstanding questions in biophysics.  

The aim of the workshop is to discuss existing efforts on understanding nonequilibrium fluctuations using biological and physical methods, but more importantly, to identify future questions in this domain and the collaborations that will help to answer them.

Key topics include:
  • Sensory systems, oscillators and memory
  • Active matter
  • Cytoskeleton and membrane dynamics
  • Molecular motors
  • Nonequilibrium thermodynamics


Invited Speakers:

Anjana Badrinarayanan, NCBS Bangalore
Urna Basu, Bose Nat. Centre for Basic Sciences, Kolkata
John Bechhoefer, Simon Fraser U.
Gili Bisker, Tel Aviv U.
Jonathon Howard, Yale U.
Jim Hudspeth, Rockefeller U.
Sabine Klapp, TU Berlin
Anatoly B. Kolomeisky, Rice U.
Sandhya Koushika, TIFR Mumbai
Vijaykumar Krishnamurthy, ICTS Bangalore
Christian Mæs, KU Leuven
Pascal Martin, Institut Curie
Juan MR Parrondo, U. Complutense de Madrid
Nenad Pavin, U. of Zagreb
Luca Peliti, SMRI Rome
Simone Pigolotti, OIST
Madan Rao, Raman Res. Institute & NCBS, Bangalore
Felix Ritort, U. of Barcelona
Pablo Sartori, IGC, Oeiras
Udo Seifert, U. of Stuttgart
Pieter Rein Ten Wolde, AMOLF
Iva Tolic, R. Boskovic Institute, Zagreb
Suri Vaikuntanathan, U. of Chicago
Jin Wang, Stony Brook U.
Christoph Zechner, MPI-CBG Dresden

DEADLINE TO SUBMIT APPLICATIONS:
7 MARCH 2023
There is no registration fee.

Scientists from under-represented groups and female scientists are encouraged to apply.

Grants:
A limited number of grants are available to support the attendance of selected participants, with priority given to participants from developing countries.


 

Material

Workshop on Signatures of Nonequilibrium Fluctuations in Life | (smr 3835)
Go to day
  • Monday, 15 May 2023
    • 08:30 - 19:30 Monday, 15 May
      • 08:30 Registration and administrative formalities 1h0' ( Leonardo Building - Lobby ) 
         Upon arrival, Visitors NOT staying at the ICTP Guest Houses, are kindly requested to complete registration formalities at the Leonardo Building, Lobby, Main entrance from 8.30 to 9.30.
Visitors lodging at the ICTP guest houses are registered at the reception desks, upon check-in.
      • 09:30 Welcome address 15' ( Leonardo Building - Budinich Lecture Hall )
      • 09:45 The ear's sensory hair cells as critical oscillators and active transducers of mechanical stimulation 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Jim Hudspeth (Rockefeller University, NYC)
        Material: Video
      • 10:10 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 10:30 Active oscillations and energy dissipation by the hair cells’ mechanosensory hair bundle 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Pascal Martin (Institut Curie, Paris)
        Material: Video
      • 10:55 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 11:15 Coffee break 25' ( Leonardo Building - Terrace )
      • 11:40 Trade-offs between cost and information in cellular prediction 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Pieter Rein ten Wolde (AMOLF, Amsterdam)
        Material: Video
      • 12:05 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 12:45 Lunch break 2h15' ( Leonardo Building - Cafeteria )
      • 15:00 Searching for homology 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Anjana Badrinarayanan (NCBS, Bangalore)
        Material: Video
      • 15:25 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 15:45 Cellular dissipation, its allocation, and the cost of growth 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Pablo Sartori (IGC Gulbenkian, Oeiras)
      • 16:10 Discussion 25' ( Leonardo Building - Budinich Lecture Hall )
      • 18:00 Welcome reception 1h30' ( Adriatico Guest House - Cafeteria Terrace )
  • Tuesday, 16 May 2023
    • 09:30 - 16:00 Tuesday, 16 May
      • 09:30 Fragile Active Matter: Segregation, Force Chains and Excitability 25'
        Speaker: Madan Rao (NCBS-TIFR, Bangalore)
        Material: Video
      • 09:55 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 10:15 Collective motion and fluctuations in colloidal systems under time-delayed feedback 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Sabine Klapp (TU Berlin)
        Material: Video
      • 10:40 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 11:00 Coffee break 25' ( Leonardo Building - Terrace )
      • 11:25 Direction reversing active Brownian motion 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Urna Basu (SN Bose NCBS, Kolkata)
        Material: Video
      • 11:50 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 12:10 GROUP PHOTO 5' ( in front of the main entrance )
      • 12:45 Lunch break 1h45' ( Leonardo Building - Cafeteria )
      • 14:30 Speed variations of bacterial replisomes 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Simone Pigolotti (OIST, Okinawa)
        Material: Video
      • 14:55 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 15:15 “Active” associative memory 25'
        Speaker: Suri Vaikuntanathan (U. of Chicago)
        Material: Video
      • 15:40 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
    • 17:00 - 19:00 POSTER SESSION and coffee break
      Location: Adriatico Guest House - Lower Level 1
  • Wednesday, 17 May 2023
    • 09:30 - 17:10 Wednesday,17 May
      • 09:30 Branching morphogenesis of neuronal dendrites: Dynamics and scaling 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Jonathon Howard (Yale University)
      • 09:55 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 10:15 The Quest for Precision: Mechanobiology of Mitotic Spindle Assembly and Chromosome Segregation 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Iva Tolic (R.Boskovic Inst., Zagreb)
        Material: Video
      • 10:40 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 11:00 Coffee break 25' ( Leonardo Building - Terrace )
      • 11:25 Exploring the evolution of tumor karyotypes through a theoretical approach based on the 'macro-karyotype' concept 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Nenad Pavin (U. of Zagreb)
        Material: Video
      • 11:50 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 12:45 Lunch break 1h45' ( Leonardo Building - Cafeteria )
      • 14:30 How To Find Targets That Are Always Hidden: The Story of Nucleosome-Covered DNA and Pioneer Transcription Factors 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Anatoly B. Kolomeisky (Rice U., Houston)
        Material: Video
      • 14:55 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 15:15 Regulation of axonal transport 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Sandhya Koushika (DBS-TIFR, Mumbai)
        Material: Video
      • 15:40 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 16:00 Coffee break 25' ( Leonardo Building - Terrace )
      • 16:25 Physics of asymmetric cytokinetic ingression 25'
        Speaker: Vijaykumar Krishnamurthy (ICTS, Bangalore)
        Material: Video
      • 16:50 Discussion 20'
  • Thursday, 18 May 2023
    • 09:30 - 16:00 Thursday, 18 May
      • 09:30 Variance Sum Rule for Entropy Production 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Felix Ritort (U. of Barcelona)
        Material: Video
      • 09:55 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 10:15 Can one experimentally identify an information engine? 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: John Bechhoefer (Simon Fraser U., Burnaby, B.C.)
      • 10:40 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 11:00 Coffee break 25' ( Leonardo Building - Terrace )
      • 11:25 Irreversibility and dissipation 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Juan MR Parrondo (U. Complutense, Madrid)
        Material: Video
      • 11:50 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 12:45 Lunch break 1h45' ( Leonardo Building - Cafeteria )
      • 14:30 Formalizing an optimization problem for inferring the entropy production from observed statistics 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Gili Bisker (Tel Aviv U.)
        Material: Reading material Video
      • 14:55 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 15:15 Control of concentration fluctuations in chemically active droplet systems 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Christoph Zechner (MPI-CBG, Dresden)
        Material: Video
      • 15:40 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
    • 16:00 - 19:00 EXCURSION
  • Friday, 19 May 2023
    • 09:30 - 14:30 Friday, 19 May
      • 09:30 Thermodynamic uncertainty relation and waiting time distributions as tools for inference 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Udo Seifert (Stuttgart U.)
        Material: Video
      • 09:55 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 10:15 Did Pinocchio's thermal response change when animated? 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Christian Maes (KU Leuven)
        Material: Video
      • 10:40 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 11:00 Coffee break 25' ( Leonardo Building - Terrace )
      • 11:25 Memory strategies for evolving patterns 25' ( Leonardo Building - Budinich Lecture Hall )
        Speaker: Luca Peliti (SMRI Rome)
        Material: Video
      • 11:50 Discussion 20' ( Leonardo Building - Budinich Lecture Hall )
      • 12:10 Landscape and flux quantification of nonequilibrium biological systems 25'
        Speaker: Jin Wang (Stony Brook U., NY)
        Material: Video
      • 12:35 Discussion and Wrap-up 30' ( Leonardo Building - Budinich Lecture Hall )
      • 12:45 Lunch break 1h45' ( Leonardo Building - Cafeteria )
    • 14:00 - 16:00 FOLLOW UP POSTER SESSION (optional)
      Location: Leonardo Building - Budinich Lecture Hall
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