Starts 1 Aug 2025 11:00
Ends 1 Aug 2025 12:00
Central European Time
QLS Seminar - Dynamics and functions of the p53 signaling network in response to various stresses
ICTP
Common Area Old SISSA building Second floor
Via Beirut, 2
Abstract:
References：
[1] X.-P. Zhang, F. Liu and W. Wang. Two-phase dynamics of p53 in the DNA damage response. Proc. Natl. Acad. Sci. USA 108, 8990 (2011).
[2] R.Yang, B. Huang, Y. Zhu, Y. Li, F. Liu and J. Shi. Cell type-dependent bimodal p53 activation engenders a dynamic mechanism of chemoresistance. Sci. Adv. 4, eaat5077 (2018).
[3] Y. Zhou and F. Liu. Coordination of the AMPK, Akt, mTOR, and p53 pathways under glucose starvation. Int. J. Mol. Sci. 23, 14945 (2022).
[4] P. Wang, X.-P. Zhang, F. Liu and W. Wang. Progressive deactivation of hydroxylases controls hypoxia-inducible factor-1α-coordinated cellular adaptation to graded hypoxia. Research 8, 0651 (2025).
As one of the most critical tumor suppressors, the p53 protein orchestrates cellular physiological activities through an intricate signaling network. Crucially, the temporal evolution of p53 concentration significantly regulates cellular stress responses. Through theoretical modeling and numerical simulations, we systematically investigated the dynamics and functions of the p53 network in response to diverse signals, such as DNA damage, oncogene activation, glucose starvation, and hypoxia. Here, I will present our representative research, highlighting the critical link between p53 dynamics and function.
References：
[1] X.-P. Zhang, F. Liu and W. Wang. Two-phase dynamics of p53 in the DNA damage response. Proc. Natl. Acad. Sci. USA 108, 8990 (2011).
[2] R.Yang, B. Huang, Y. Zhu, Y. Li, F. Liu and J. Shi. Cell type-dependent bimodal p53 activation engenders a dynamic mechanism of chemoresistance. Sci. Adv. 4, eaat5077 (2018).
[3] Y. Zhou and F. Liu. Coordination of the AMPK, Akt, mTOR, and p53 pathways under glucose starvation. Int. J. Mol. Sci. 23, 14945 (2022).
[4] P. Wang, X.-P. Zhang, F. Liu and W. Wang. Progressive deactivation of hydroxylases controls hypoxia-inducible factor-1α-coordinated cellular adaptation to graded hypoxia. Research 8, 0651 (2025).