Starts 30 Apr 2026 11:00
Ends 30 Apr 2026 12:00
Central European Time
CMSP News and Views Seminar Series: Modeling of equilibrium and non-equilibrium time-series data: from protein folding to weather forecasting
Luigi Stasi Seminar Room (Leonardo Building) and via Zoom
Roland R. Netz
(Free University Berlin)
Abstract:
Most systems of scientific interest are interacting many-body systems. One typically describes their kinetics in terms of a low-dimensional reaction coordinate, which in general is influenced by the entire system. The dynamics of such a reaction coordinate is governed by the generalized Langevin equation (GLE), an integro-differential stochastic equation, and involves a memory function [1]. I discuss a few examples where the GLE can be used to interpret and model data in different fields of science.
Protein-folding kinetics is often described as Markovian (i.e., memoryless) diffusion in a one-dimensional free energy landscape. By analysis of large-scale molecular-dynamics simulation trajectories of fast-folding proteins from the Shaw group using the special-purpose computer ANTON, I demonstrate that the friction characterizing protein folding exhibits significant memory with a decay time that is of the same order as the folding and unfolding times [2]. Memory friction effects lead to anomalous and drastically modified protein kinetics [3]. For the set of proteins for which simulations are available, it is shown that the folding and unfolding times are not dominated by the free-energy barrier but rather by the non-Markovian friction.
Memory effects are also present for non-equilibrium systems. Using an appropriate non-equilibrium formulation of the GLE, it is demonstrated that the motion of living organisms is characterized by memory friction, which allows to characterize internal feedback loops of such organisms and to classify and sort individual organisms [3]. The GLE can be even used to predict complex phenomena such as weather data [4].
Protein-folding kinetics is often described as Markovian (i.e., memoryless) diffusion in a one-dimensional free energy landscape. By analysis of large-scale molecular-dynamics simulation trajectories of fast-folding proteins from the Shaw group using the special-purpose computer ANTON, I demonstrate that the friction characterizing protein folding exhibits significant memory with a decay time that is of the same order as the folding and unfolding times [2]. Memory friction effects lead to anomalous and drastically modified protein kinetics [3]. For the set of proteins for which simulations are available, it is shown that the folding and unfolding times are not dominated by the free-energy barrier but rather by the non-Markovian friction.
Memory effects are also present for non-equilibrium systems. Using an appropriate non-equilibrium formulation of the GLE, it is demonstrated that the motion of living organisms is characterized by memory friction, which allows to characterize internal feedback loops of such organisms and to classify and sort individual organisms [3]. The GLE can be even used to predict complex phenomena such as weather data [4].
[1] Memory and Friction: From the Nanoscale to the Macroscale
Benjamin A. Dalton ... Roland R. Netz
Annu. Rev. Phys. Chem. 76, 431–54 (2025)
[2] Fast protein folding is governed by memory-dependent friction
Benjamin A. Dalton ... Roland R. Netz
Proc. Natl Acad. Sci. 120, e2220068120 (2023)
[3] Hierarchical friction memory leads to subdiffusive configurational dynamics of fast-folding proteins
Anton Klimek, Benjamin A. Dalton, Lucas Tepper, Roland R. Netz
PNAS 123 e2516506123 (2026)
[4] Intrinsic Cell-to-Cell Variance from Experimental Single-Cell Motility Data
Anton Klimek ... Roland R. Netz
PRX Life 3, 023015 (2025)
[5] Prediction of weather and financial time-series data via a Hamiltonian-based filter-projection approach
Henrik Kiefer ... Roland R. Netz
Newton 1, 100138 (2025)