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SUMMARY:QLS Seminar - Model of Sperm–Oocyte Penetration Mechanisms
DTSTART;VALUE=DATE-TIME:20260515T113000Z
DTEND;VALUE=DATE-TIME:20260515T123000Z
DTSTAMP;VALUE=DATE-TIME:20260525T171120Z
UID:indico-event-11352@ictp.it
DESCRIPTION:\n	Existing theories of sperm–oocyte penetration can be clas
 sified into three main categories: biochemical receptor–mediated mechani
 sms\, maximum normal stress–based penetration\, and oscillatory relaxati
 on mechanisms. Previous mechanical probing studies of zona pellucida (ZP) 
 demonstrate increased structural resistance under higher perpendicular loa
 ding\, implying that penetration is favored along directions of reduced me
 chanical resistance. Experimental observations indicate that sperm penetra
 tion of the ZP follows an oblique trajectory. Motivated by these findings\
 , a modified mechanical model of ZP deformation is proposed to quantify no
 rmal and shear stresses generated during plastic sperm–oocyte collision.
  Numerical simulations were conducted for three distinct sperm distributio
 n scenarios over the ZP surface. The results show time-dependent oscillati
 ons of both normal and shear stresses\, with normal stress consistently ex
 ceeding shear stress across all scenarios. The observed stress fluctuation
 s may contribute to oscillatory states of the ZP and could play a signific
 ant role in the mechanical mechanism of sperm penetration. The theory of p
 hase transition of ZP as a potential mechanism of sperm penetration will b
 e discussed.\n\n//indico.ictp.it/event/11352/
LOCATION:ICTP Common Area Old SISSA building\,  Second floor
URL://indico.ictp.it/event/11352/
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