2nd Conference on Drug Development for the Third World: from Computational Molecular Biology to Experimental Approaches

Administration

Material

Final List of Participants 2039.pdf Poster Abstract announcement

2nd Conference on Drug Development for the Third World: from Computational Molecular Biology to Experimental Approaches | (smr 2039)

Go to day

Monday, 1 June 2009

08:30 - 08:40 Welcome on behalf of the Organizers
- 08:30 Welcome on behalf of the Organizers 10'
  
  Speaker: E. LATTMAN (Hauptman Woodward Medical Research Institute, Buffalo, U.S.A.)
08:40 - 08:50 Welcome on behalf of ICTP
- 08:40 Welcome on behalf of ICTP 10'
  
  Speaker: S. RANDJBAR-DAEMI (Assistant Director)
08:50 - 09:00 Welcome on behalf of ICS/UNIDO
- 08:50 Welcome on behalf of ICS/UNIDO 10'
  
  Speaker: S. MIERTUS (ICS/UNIDO, Padriciano, Trieste, Italy)
09:00 - 09:10 Organizational Remarks
- 09:00 Organizational Remarks 10'
  
  Speaker: P. CARLONI (SISSA, Trieste, Italy)

09:10 - 09:50 Modes of Drug Action I

09:10 Modes of Drug Action I 40'

Speaker:	W.G.J. HOL (Biomolecular Structure Centre, Univ. of Washington, Seattle, WA, U.S.A.)
Material:	lecture notes

09:50 - 10:30 The Art and Science of Protein Structure Determination
- 09:50 The Art and Science of Protein Structure Determination 40'
  
  Speaker: E. LATTMAN (Hauptman Woodward Medical Research Centre, Buffalo, U.S.A.)
10:30 - 11:00 Coffee break
- 10:30 Coffee break 30'
10:30 - 11:30 REGISTRATION FORMALITIES (outside Kastler Lecture Hall) subsequently with the secretariat room office nr. 2

Location: Adriatico Guest House - Kastler Lecture Hall Area (Lower Level 1)
- 10:30 REGISTRATION FORMALITIES (outside Kastler Lecture Hall) subsequently with the secretariat room office nr. 2 1h0'
11:30 - 12:10 Computational Strategies in Drug Discovery and Design
- 11:30 Computational Strategies in Drug Discovery and Design 40'
  
  Speaker: R. NUSSINOV (NCI at Frederick, Computational Structural Biology Group, Frederick, MD, U.S.A.)
12:10 - 14:30 Lunch break
- 12:10 Lunch break 2h20'
13:00 - 14:30 Registration - continued with the secretariat, AGH office room nr. 2
- 13:00 Registration - continued with the secretariat, AGH office room nr. 2 1h30'
14:30 - 15:00 Principles and Scope of Radiotracers and Related Techniques in Drug Development
- 14:30 Principles and Scope of Radiotracers and Related Techniques in Drug Development 30'
  
  Speaker: N. RAMAMOORTHY (IAEA, Vienna, Austria)
15:00 - 15:30 Coffee break
- 15:00 Coffee break 30'
15:30 - 16:10 PET in Drug Discovery and Development
- 15:30 PET in Drug Discovery and Development 40'
  
  Speaker: A. GEE (Clinical Imaging Centre, Imperial College London, U.K.)
16:10 - 16:50 Role of Labelled Compounds in Drug Development and Manufacture: Indian experience
- 16:10 Role of Labelled Compounds in Drug Development and Manufacture: Indian experience 40'
  
  Speaker: N. SIVAPRASAD (BRIT, BARC Vashi Complex, Mumbai, India)

16:50 - 17:10 Presentation of SISSA's Bioinformatics Laboratory, where on the 6th and 7th of June, participants taking part in the Training Course (week 8-12 June) will be working.

In this laboratory, students will be able to visualize the molecular structure of proteins and to perform protein structure based on webservers.

16:50 Presentation of SISSA's Bioinformatics Laboratory, where on the 6th and 7th of June, participants taking part in the Training Course (week 8-12 June) will be working. 20'

Speaker:

A. GIORGETTI, S. PANTANO and E. IPPOLITI (Univ.Verona, Biotechnologie, Italy/ Inst.Pasteur Montevideo, Uruguay/ SISSA, Trieste, Italy)

Tuesday, 2 June 2009

09:00 - 09:40 Biological and Chemical Considerations for the Development of Drugs Targeting HIV-1 Reverse Transcriptase
- 09:00 Biological and Chemical Considerations for the Development of Drugs Targeting HIV-1 Reverse Transcriptase 40'
  
  Speaker: S.H. HUGHES (NIH/NCI at Frederick, MD, U.S.A.)
09:40 - 10:20 Structure-based Design of Drugs and Vaccines for Treatment and Prevention of HIV infection
- 09:40 Structure-based Design of Drugs and Vaccines for Treatment and Prevention of HIV infection 40'
  
  Speaker: E. ARNOLD (CABM and Rutgers Univ., Piscataway, U.S.A.)
10:20 - 10:50 Coffee break
- 10:20 Coffee break 30'
10:50 - 11:30 Development of four anti-AIDS Drugs: Successes and Challenges
- 10:50 Development of four anti-AIDS Drugs: Successes and Challenges 40'
  
  Speaker: H. MITSUYA (NIH/NCI at Bethesda, MD, USA and Kumamoto Univ., Japan)
11:30 - 12:10 Developing Successful Microbicides for Blocking HIV Transmission
- 11:30 Developing Successful Microbicides for Blocking HIV Transmission 40'
  
  Speaker: M.A. PARNIAK (Univ. of Pittsburgh, School of Medicine, U.S.A.)
12:10 - 13:20 Lunch Break
- 12:10 Lunch Break 1h10'

13:20 - 14:00 Modes of Drug Action II

13:20 Modes of Drug Action II 40'

Speaker:	W.G.J. HOL (Biomolecular Structure Centre, Univ. of Washington, Seattle, U.S.A.)
Material:	lecture notes

14:00 - 14:40 Structural biology in Drug Design
- 14:00 Structural biology in Drug Design 40'
  
  Speaker: W.G.J. HOL (Biomolecular Structure Centre, Univ. of Washington, Seattle, U.S.A.)
14:40 - 15:10 Coffee break
- 14:40 Coffee break 30'

15:10 - 15:50 Forces and Energies I

15:10 Forces and Energies I 40'

Speaker:	C.L.M.J. VERLINDE (Biomolecular Structure Centre, Univ. of Washington, Seattle, U.S.A.)
Material:	lecture notes

15:50 - 16:30 Forces and Energies II

15:50 Forces and Energies II 40'

Speaker:	C.L.M.J. VERLINDE (Biomolecular Structure Centre, Univ. of Washington, Seattle, U.S.A.)
Material:	lecture notes

Wednesday, 3 June 2009

08:30 - 09:10 Targeting the Malaria Parasite's Invasion Machinery

08:30 Targeting the Malaria Parasite's Invasion Machinery 40'

Speaker:	W.G.J. HOL (Biomolecular Structure Center, Univ. of Washington, Seattle, U.S.A.)
Material:	lecture notes

09:10 - 09:50 Molecular Simulation and Drug Design
- 09:10 Molecular Simulation and Drug Design 40'
  
  Speaker: P. CARLONI (SISSA, Trieste, Italy)
09:50 - 10:30 The TDR Drug Target Database
- 09:50 The TDR Drug Target Database 40'
  
  Speaker: C.L.M.J. VERLINDE (Biomolecular Structure Center, Univ. of Washington, Seattle, U.S.A.)
10:30 - 11:00 Coffee break
- 10:30 Coffee break 30'
11:00 - 11:40 Characterization and Targeting of Trypanosomatid Pteridine Reductase
- 11:00 Characterization and Targeting of Trypanosomatid Pteridine Reductase 40'
  
  Speaker: W.N. HUNTER (Univ. of Dundee, Life Sciences, Dundee, U.K.)
11:40 - 12:20 Glycolytic Targets in Trypanosomatids
- 11:40 Glycolytic Targets in Trypanosomatids 40'
  
  Speaker: M.D. WALKINSHAW (Univ. of Edinburgh, Structural Biochemistry, Edinburgh, U.K.)
12:20 - 13:30 Lunch break
- 12:20 Lunch break 1h10'
13:30 - 14:10 Solvation
- 13:30 Solvation 40'
  
  Speaker: C.L.M.J. VERLINDE (Biomolecular Structure Centre, Univ. of Washington, Seattle, U.S.A.)
14:10 - 14:50 Molecular Modelling Study, Design and Development of New Anti-dengue Compounds
- 14:10 Molecular Modelling Study, Design and Development of New Anti-dengue Compounds 40'
  
  Speaker: N.B. Abd. RAHMAN (Univ. of Malaya, Chemistry, Kuala Lumpur, Malaysia)
14:50 - 15:30 Computer Drug Design and Computer Assisted Combinatorial Chemistry: Applications for Anti-bird Flu and Anti-HIV Drugs
- 14:50 Computer Drug Design and Computer Assisted Combinatorial Chemistry: Applications for Anti-bird Flu and Anti-HIV Drugs 40'
  
  Speaker: V. FRECER (ICS/UNIDO, Padriciano, Trieste, Italy)
15:30 - 16:00 Coffee break
- 15:30 Coffee break 30'
16:00 - 16:40 Molecular Modeling of New Targets Against AIDS
- 16:00 Molecular Modeling of New Targets Against AIDS 40'
  
  Speaker: S. PANTANO (Inst. Pasteur de Montevideo, Uruguay)
16:40 - 17:20 Drug Discovery Using Combinatorial Chemistry Approaches
- 16:40 Drug Discovery Using Combinatorial Chemistry Approaches 40'
  
  Speaker: P. SENECI (Univ. of Milan, Dept. of Organic & Industrial Chemistry, Milan, Italy)
17:20 - 17:50 Knowledge Based Identification and Prioritization of Potent Anti-tubercolar Compounds Using Structure-based Virtual Screening and Structure Interaction Fingerprints
- 17:20 Knowledge Based Identification and Prioritization of Potent Anti-tubercolar Compounds Using Structure-based Virtual Screening and Structure Interaction Fingerprints 30'
  
  Speaker: I. SIDDIQI (Central Drug Research Institute, Lucknow, India)

Thursday, 4 June 2009

08:30 - 09:10 Modes of Drug Resistance
- 08:30 Modes of Drug Resistance 40'
  
  Speaker: W.G.J. HOL (Biomolecular Structure Center, Univ. of Washington, Seattle, U.S.A.)
09:10 - 09:50 Immunophilins as Anti-infective Drug Targets
- 09:10 Immunophilins as Anti-infective Drug Targets 40'
  
  Speaker: M. D. WALKINSHAW (Univ. of Edinburgh, Structural Biochemistry, Edinburgh, U.K.)

09:50 - 10:30 Multivalent Drugs and Diarrheal Diseases

09:50 Multivalent Drugs and Diarrheal Diseases 40'

Speaker:	W.G.J. HOL (Biomolecular Structure Centre, Univ. of Washington, Seattle, U.S.A.)
Material:	lecture notes

10:30 - 11:00 Coffee break
- 10:30 Coffee break 30'
11:00 - 11:40 Multifunctional strategies in the search for novel lead candidates against Trypanosoma and Leishmania
- 11:00 Multifunctional strategies in the search for novel lead candidates against Trypanosoma and Leishmania 40'
  
  Speaker: A. CAVALLI (Univ. of Bologna, Dept. of Pharmaceutical Sciences, Bologna, Italy)
11:40 - 12:20 Bio-informatics and Structural Biology Approaches to the Development of Anti-malaria Compounds
- 11:40 Bio-informatics and Structural Biology Approaches to the Development of Anti-malaria Compounds 40'
  
  Speaker: A. SHARMA PRAKASH (ICGEB, New Delhi, India)
12:20 - 13:30 Lunch Break
- 12:20 Lunch Break 1h10'
13:30 - 14:10 Scoring Functions
- 13:30 Scoring Functions 40'
  
  Speaker: C.L.M.J. VERLINDE (Biomolecular Structure Center, Univ. of Washington, Seattle, U.S.A.)
14:10 - 14:50 Docking
- 14:10 Docking 40'
  
  Speaker: C.L.M.J. VERLINDE (Biomolecular Structure Center, Univ. of Washington, Seattle, U.S.A.)
14:50 - 15:20 Coffee break
- 14:50 Coffee break 30'
15:20 - 16:50 POSTER SESSION

Location: Adriatico Guest House - Kastler Lecture Hall Area (Lower Level 1)
- 15:20 POSTER SESSION 1h30'
  
  Speaker: Presentation of Poster Contributions

Friday, 5 June 2009
- 08:30 - 09:10 The Non-mevalonate Pathway of Isoprenoid Biosynthesis; Essential Activities in Apicomplexans and Gram-negative Bacteria
  - 08:30 The Non-mevalonate Pathway of Isoprenoid Biosynthesis; Essential Activities in Apicomplexans and Gram-negative Bacteria 40'
    
    Speaker: W.N. HUNTER (Univ. of Dundee, Life Sciences, Dundee, U.K.)
- 09:10 - 09:50 Drug Discovery Research in an Academic Environment
  - 09:10 Drug Discovery Research in an Academic Environment 40'
    
    Speaker: W.N. HUNTER (Univ. of Dundee, Life Sciences, Dundee, U.K.)
- 09:50 - 10:20 Coffee break
  - 09:50 Coffee break 30'
- 10:20 - 11:00 Absorption, Distribution, Metabolism, Excretion I
  - 10:20 Absorption, Distribution, Metabolism, Excretion I 40'
    
    Speaker: C.L.M.J. VERLINDE (Biomolecular Structure Center, Univ. of Washington, Seattle, U.S.A.)
- 11:00 - 11:40 Absorption, Distribution, Metabolism, Excretion II
  - 11:00 Absorption, Distribution, Metabolism, Excretion II 40'
    
    Speaker: C.L.M.J. VERLINDE (Biomolecular Structure Center, Univ. of Washington, Seattle, U.S.A.)
- 11:40 - 12:20 Flexibility and Drug Design
  - 11:40 Flexibility and Drug Design 40'
    
    Speaker: B. DE GROOT (Max Planck Inst. for Biophysical Chemistry, Gottingen, Germany)
- 12:20 - 12:30 Lunch Break
  - 12:20 Lunch Break 10'
- 13:30 - 14:10 Structures of M. Tuberculosis Drug Targets
  - 13:30 Structures of M. Tuberculosis Drug Targets 40'
    
    Speaker: W.G.J. HOL (Biomolecular Structure Center, Univ. of Washington, Seattle, U.S.A.)
- 14:10 - 14:50 Protein Structures for Drug Design Against Tropical Protozoa
  - 14:10 Protein Structures for Drug Design Against Tropical Protozoa 40'
    
    Speaker: W.G.J. HOL (Biomolecular Structure Center, Univ. of Washington, Seattle, U.S.A.)
- 14:50 - 15:30 Design of New Anti-Chagas Therapeutics
  - 14:50 Design of New Anti-Chagas Therapeutics 40'
    
    Speaker: C.L.M.J. VERLINDE (Biomolecular Structure Center, Univ. of Washington, Seattle, U.S.A.)
- 15:30 - 16:00 Coffee break
  - 15:30 Coffee break 30'
- 16:00 - 16:40 Spatial and Temporal Correlates of Viral Replication in Single Cells in Real Time
  - 16:00 Spatial and Temporal Correlates of Viral Replication in Single Cells in Real Time 40'
    
    Speaker: A. MARCELLO (ICGEB, Molecular Virology Lab., Padriciano, Trieste, Italy)
- 16:40 - 17:20 Molecular Mechanisms Regulating HIV-1 Integration and Latency
  - 16:40 Molecular Mechanisms Regulating HIV-1 Integration and Latency 40'
    
    Speaker: M. LUSIC (ICGEB, Molecular Medicine)
- 17:20 - 17:35 CONCLUDING REMARKS
  - 17:20 CONCLUDING REMARKS 15'
    
    Speaker: W.G.J. HOL / P. CARLONI / E. LATTMAN