We have recently developed a powerful algorithm to predict protein-RNA associations that we validate using a series of assays including immunoprecipitation of protein-RNA complexes.  At the same time, we work on the prediction of interactomes of amyloid fibrils in the cellular context and develop models for calculating the interaction  potential with molecular chaperones.  A series of bioinformatics tools to predict toxicity under a variety of experimental conditions will be presented.