| Description | The Abdus Salam International Centre for Theoretical Physics (ICTP, Trieste, Italy) is organizing the above workshop to take place at the ICTP from 23 to 27 June 2014. In recent years the dynamics of biological systems has been increasingly described using concepts and terminology borrowed from economics: cells face trade-offs between different strategies for survival; the generation of proteins from DNA displays multiple levels of subtle, optimal efficiency; metabolism can be viewed as a resource allocation problem; biomolecules can be associated with a “value” within the free energy “market” of the cell. These concepts indicate the emergence of a new way of thinking about problems in biology. We envisage that innovation in several important areas of biology can ensue from exploring in more depth and in a more coherent way this connection between cellular dynamics and concepts traditionally used in economics. The purpose of this workshop is to bring together systems biologists and physicists whose research has brought them to an economy-inspired view of the cell. Scientists from different backgrounds will discuss biological questions that can be addressed using concepts of resource allocation, efficiency and optimality. The following topics will be covered: (1) Genome-scale cellular metabolism and the global molecular budget of a cell; (2) The economy of gene expression and protein synthesis: the cellular adaptations to translational efficiency; (3) Benefits and costs in cellular fitness; (4) Trade-offs and Pareto-optimality in biological systems; (5) Game theory in cellular and multicellular biology; and (6) Economics of cognitive-like processes at the cellular level. | 
Workshop on the Economy of a Cell: Resource Allocation, Trade-Offs and Efficiency in Living Systems | (smr 2588)
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            09:00 - 19:00
        
        
        
            
        
        
    
    - 09:00 ARRIVAL REGISTRATION - Desk - lobby, Leonardo da Vinci building 1h15' ( Leonardo da Vinci Building Euler Lecture Hall )
- 10:15 Coffee break 30' ( Leonardo da Vinci Building Euler Lecture Hall )
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        10:45
    
    
        Welcome message
            15'                        (
    
        
            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Workshop Directors 
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        11:00
    
    
        Intro Lecture 1
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            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Tzachi Pilpel (Weizmann Institute of Science, Rehovot) 
- 12:30 Lunch break 1h30' ( Leonardo da Vinci Building Euler Lecture Hall )
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        14:00
    
    
        Introduction Lecture 2: An Introduction to Flux Balance Analysis and related methods for studying metabolic genotype-phenotype relationships
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            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Areejit Samal (ICTP - Trieste) 
- 15:15 Coffee break 30' ( Leonardo da Vinci Building Euler Lecture Hall )
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        15:45
    
    
        Intro Lecture 3
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    Speaker: Daniel Segrè (Boston University) 
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        17:00
    
    
        POSTER SESSION (Poster Gallery)
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            Leonardo da Vinci Building, Lobby
        
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            09:00 - 19:00
        
        
        
            
        
        
    
    
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            09:00 - 22:00
        
        
        
            
        
        
    
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        Keynote Speaker - Codon usage as a window into cellular economics
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    Speaker: Lawrence Hurst (University of Bath) 
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        10:00
    
    
        Plenary Speaker - Competing Endogenous RNAs:[ceRNAs]: post-transcriptional competition for limited resources
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    Speaker: Andrea Pagnani (Institute for Scientific Interchange Foundation (ISI), Turin) 
- 10:40 Coffee break 30' ( Leonardo da Vinci Building Euler Lecture Hall )
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        11:10
    
    
        Plenary Speaker - Towards Quantitative Endogenous Network Theory of Cancer Genesis and Progression: beyond cancer as disease of genome
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            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Ping Ao (Shanghai Jiao Tong University) Material:  lecture notes lecture notes
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        11:50
    
    
        Plenary Speaker - Characterizing multi-drug treatments on metabolic networks
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    Speaker: Claudio Altafini (International School for Advanced Studies (SISSA) Trieste) Material:  lecture notes lecture notes
- 12:30 Lunch break 1h30' ( Leonardo da Vinci Building Euler Lecture Hall )
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        Keynote Speaker - Growth laws and metabolic coordination
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    Speaker: Terence Hwa (University of California at San Diego, La Jolla) 
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        15:00
    
    
        Plenary Speaker - Constrained-allocation FBA: modeling the interplay of regulation and metabolism in bacteria at genome scale
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            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Andrea De Martino (University of Rome "La Sapienza") Material:  abstract abstract lecture notes lecture notes
- 15:40 Coffee break 30' ( Leonardo da Vinci Building Euler Lecture Hall )
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        16:10
    
    
        Keynote Speaker - What's in a proteome? Lessons from a visual account of protein investment in cellular functions.
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    Speaker: Ron Milo (The Weizmann Institute of Science, Rehovot) Material:  lecture notes lecture notes
- 20:00 Reception 2h0' ( Leonardo da Vinci Building Euler Lecture Hall )
 
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        09:00
    
    
        Keynote Speaker - Codon usage as a window into cellular economics
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            09:00 - 22:00
        
        
        
            
        
        
    
    
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            09:00 - 14:00
        
        
        
            
        
        
    
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        Laboratory evolution of bacteria
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    Speaker: Christopher Marx - Keynote Speaker (Harvard University, Massachusetts) Material:  lecture notes lecture notes
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        10:00
    
    
        Towards a quantitative analysis of the "Competing Endogenous RNA effect"
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    Speaker: Carla Bosia - Contributed speaker (University of Turin) Material:  abstract abstract
- 10:30 Coffee break 20' ( Leonardo da Vinci Building Euler Lecture Hall )
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        10:50
    
    
        Motility and collective phenomena
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    Speaker: Antonio Celani - Plenary Speaker (Institut Pasteur, Paris) 
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        11:30
    
    
        Flux sensing
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    Speaker: Matthias Heinemann - Keynote Speaker (University of Groningen) 
- 12:30 Lunch break 1h30' ( Leonardo da Vinci Building Euler Lecture Hall )
 
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        Laboratory evolution of bacteria
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            09:00 - 19:00
        
        
        
            
        
        
    
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        Keynote Speaker - What matters in the cell: Economy or speed?
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    Speaker: Stefan Schuster (Friedrich Schiller University, Jena) 
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        10:00
    
    
        Plenary Speaker - The costs and benefits of microbial procrastination
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    Speaker: Mike Springer (Harvard University, Cambridge) Material:  lecture notes lecture notes
- 10:40 Coffee break 40' ( Leonardo da Vinci Building Euler Lecture Hall )
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        11:20
    
    
        A toy model for dynamic metabolic adaptations
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            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Benjamin Pfeuty - Contributed speaker (CNRS - University Lille 1, Villeneuve D'Ascq, France) Material:  abstract abstract
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        11:50
    
    
        Uniform sampling of steady states in metabolic networks: scales heterogeneity and ill-conditioning
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    Speaker: Daniele De Martino - Conributed speaker (Center for Life Nanoscience, Rome) Material:  abstract abstract
- 12:20 Lunch break 1h30' ( Leonardo da Vinci Building Euler Lecture Hall )
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        The energetic cost of cellular computation
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    Speaker: Pankaj Mehta - Keynote Speaker (Rutgers State University) 
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        15:00
    
    
        Identification of pathway regulation in prokaryotes using dynamic optimization
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    Speaker: D. Schuster (Friedrich-Schiller-Universitaet, Jena) Material:  abstract abstract
- 15:30 Coffee break 30' ( Leonardo da Vinci Building Euler Lecture Hall )
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        16:00
    
    
        Phenotypic Heterogeneity in Bacteria: on Noise in Metabolism and Growth
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            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Daniel J. Kiviet - Contributed speaker (ETH Zurich) Material:  abstract abstract
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        16:30
    
    
        How the cell balances resources and tasks: Evaluating the Efficiency of Metabolic Networks
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            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Lorenzo Castelli - Contributed speaker (University of Trieste) Material:  abstract abstract
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        17:00
    
    
        POSTER SESSION (Poster Gallery)
            2h0'                        (
    
        
            Leonardo da Vinci Building, Lobby
        
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        09:00
    
    
        Keynote Speaker - What matters in the cell: Economy or speed?
            1h0'                        (
    
        
            Leonardo da Vinci Building Euler Lecture Hall
        
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            09:00 - 19:00
        
        
        
            
        
        
    
    
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            09:00 - 13:00
        
        
        
            
        
        
    
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        09:00
    
    
        Universal Distribution of Component Frequencies in Biological and Technological Networks
            1h0'                        (
    
        
            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Sergei Maslov - Keynote Speaker (Brookhaven National Laboratory, Upton (NY)) Material:  lecture notes lecture notes
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        10:00
    
    
        Enzyme economy in metabolic networks
            30'                        (
    
        
            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Wolfram Liebermeister - Contributed speaker (Institut fuer Biochemie, Berlin) Material:  abstract abstract lecture notes lecture notes
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        10:30
    
    
        Logic of global transcriptional regulation for integrated carbon nitrogen metabolism of Escherichia coli
            30'                        (
    
        
            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Cheol-Min Ghim - Contributed speaker (Ulsan National Institute of Science and Technology, Rep. of Korea) Material:  abstract abstract
- 11:00 Coffee break 20' ( Leonardo da Vinci Building Euler Lecture Hall )
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        11:20
    
    
        Plenary Speaker - Trade-offs and resource allocation in toy mathematical models of growing-dividing cells
            40'                        (
    
        
            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Sanjay Jain (University of Delhi) 
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        12:00
    
    
        Keynote Speaker - Optimality principles in plant energy metabolism
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            Leonardo da Vinci Building Euler Lecture Hall
        
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    Speaker: Oliver Ebenhoeh (University of Aberdeen) Material:  abstract abstract
 
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        09:00
    
    
        Universal Distribution of Component Frequencies in Biological and Technological Networks
            1h0'                        (
    
        
            Leonardo da Vinci Building Euler Lecture Hall
        
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            09:00 - 13:00
        
        
        
            
        
        
    
    
 LIST of POSTERS to be presented
    
    
        
        LIST of POSTERS to be presented