The Abdus Salam International Centre for Theoretical Physics (ICTP), Trieste, Italy, is organizing an 
Advanced Workshop on "Interdisciplinary View in Chromosome Structure & Function", to be held 
in Trieste, Italy, from 15 - 19 September 2014. 

Understanding how the genetic material is organized in space in eukaryotes and bacteria is one of the big challenges of current molecular biology. It is now clear that the complexity of the cellular machinery is so profound that its full comprehension can be pursued only through the joint efforts of scientists coming from cross-related disciplines like molecular biology, systems biology, bioinformatics and physics. This Workshop aims at bringing scientists from these different disciplines in a real interdisciplinary context. 
The state-of-the-art of experimental, modeling and physical aspects in chromosome organization will be discussed, with particular emphasis on future important challenges. 

Topics include: 
-High-throughput and imaging methods for chromosome structure and dynamics; 
-Gene regulatory networks in eukaryotes and bacteria: experiments and modeling; 
- Large-scale physical modeling and simulation of chromosome structure; 
- System biology of gene expression and regulation. 
Go to day
  • Monday, 15 September 2014
    • 08:15 - 18:00
      • 08:15 Registration 45'
      • 09:00 Welcome opening by the Organizers 30'
      • 09:30 Chromatin folding in oestrogen regulated transcription 45'
        Speaker: Kerstin Bystricky ((University of Toulouse, France))
      • 10:15 Coffee break 30'
      • 10:45 Two ways to fold the genome 45'
        Speaker: Job Dekker ((University of Massachussetts, USA))
      • 11:30 Does color have a structure? Modeling 3D domains of the fly genome 45'
        Speaker: Marc Marti-Renom ((CNAG-Center for Genomic Regulation, Barcelona, Spain))
      • 12:15 Protein interaction and transport maps of live cell nuclei using a single plane illumination microscope with fluorescence correlation spectroscopy 30'
        Speaker: Joerg Langowski ((German Cancer Research Center, Heidelberg, Germany))
      • 12:45 Exploring the dynamic landscape of 3D genome structures by population-based modeling 30'
        Speaker: Frank Alber ((University of Southern California, Los Angeles, USA))
      • 13:15 Lunch 1h30'
      • 14:30 A Statistical Mechanics point of view on the long range correlations in DNA sequences 45'
        Speaker: Michele Caselle ((University of Turin, Italy))
      • 15:15 Gene expression and long-range cooperativity on DNA 45'
        Speaker: Jose M. Vilar ((University of the Basque Country, Bilbao, Spain))
      • 16:00 Coffee Break 30'
      • 16:30 ChIP-Seq analysis of regulatory evolution in 20 mammals 45'
        Speaker: Diego Villar Lozano ((Wellcome Trust Sanger Institute, Hinxton, UK))
      • 17:15 Understanding cellular heterogeneity 45'
        Speaker: Sarah Teichmann ((EMBL-European Bioinformatics Institute & Wellcome Trust Sanger Institute, Hinxton, UK))
  • Tuesday, 16 September 2014
    • 09:15 - 18:00
      • 09:15 Imaging and modeling the dynamic genome architecture of yeast 45'
        Speaker: Christophe Zimmer ((Institut Pasteur, Paris, France))
      • 10:00 Coffee break 30'
      • 10:30 The bewildering ballet of chromosomes in meiosis 45'
        Speaker: Olivier Martin ((University Paris-Sud, France))
      • 11:15 Nuclear genome organization explored by dynamic studies in live cells 30'
        Speaker: Yuval Garini ((Bar Ilan University, Ramat Gan, Israel))
      • 11:15 Top-down modeling of chromosome organization from Hi-C data 45'
        Speaker: Leonid Mirny ((Massachussetts Institute of Technology, USA))
      • 11:45 Modelling three-dimensional genome structure in eukaryotes: Bridging-induced chromosome organisation & topological domains 45'
        Speaker: Davide Marenduzzo ((University of Edinburgh, UK))
      • 12:30 Lunch 2h0'
      • 14:30 DNA segregation in E. coli: When chromosome structuring really matters 45'
        Speaker: Ivan Junier ((Center for Genomic Regulation, Barcelona, Spain))
      • 15:15 The interaction of chromatin with multi-Cys2His2 zinc finger proteins 45'
        Speaker: Dieter W. Heermann ((University of Heidelberg, Germany))
      • 16:00 Coffee break 30'
      • 16:30 Predicting 3D folding of the fly genome 45'
        Speaker: Pascal Carrivain ((Institute for Human Genetics, Montpellier, France))
      • 17:15 Combined effects of self-adhesion and bridging in a prototypical nucleoid-inspired model 45'
        Speaker: Marco Cosentino-Lagomarsino ((University "Pierre et Marie Curie", Paris, France))
  • Wednesday, 17 September 2014
    • 09:15 - 17:45
      • 09:15 The "crumpled" Physics of chromosomes 45'
        Speaker: Ralf Everaers ((Ecole Normale Supérieure de Lyon, France))
      • 10:00 Coffee break 30'
      • 10:30 Colocalization of coregulated genes: A steered Molecular Dynamics study of human chromosome 19 45'
        Speaker: Cristian Micheletti ((Sissa, Trieste, Italy))
      • 11:15 The mechanical genome 45'
        Speaker: Helmut Schiessel ((University of Leiden, The Netherlands))
      • 12:00 Describing conformational fluctuations in chromatin: The case of the X inactivation centre 45'
        Speaker: Guido Tiana ((University of Milan, Italy))
      • 12:45 Lunch 1h45'
      • 14:30 Single-cell Hi-C and functional organization of the nucleus 45'
        Speaker: Peter Fraser ((The Babraham Institute, Cambridge, UK))
      • 15:15 Coffee break 30'
      • 15:45 Poster Session. Best 4-5 posters will be selected for short (15 mins) oral presentations (to be given on Thursday 2h0'
  • Thursday, 18 September 2014
    • 09:15 - 18:00
      • 09:15 Towards a 3D genome browser 45'
        Speaker: Julien Mozziconacci ((University "Pierre et Marie Curie", Paris, France))
      • 10:00 Coffee break 30'
      • 10:30 Modelling the link between genome structure and function in single cell prokaryotes and eukaryotes 45'
        Speaker: Justin O'Sullivan ((University of Auckland, New Zealand))
      • 11:15 Chromosome organization in yeast: A dynamic point of view 45'
        Speaker: Emmanuelle Fabre ((Institut Pasteur, Paris, France))
      • 12:00 Chromatin remodelers and the dynamic chromatin response to DNA damage 45'
        Speaker: Andrew Seeber (("Friedrich Miescher" Institute, Basel, Switzerland))
      • 12:45 Lunch 1h45'
      • 14:30 Nucleosome mediated epigenetics 45'
        Speaker: Kim Sneppen (("Niels Bohr" Institute, Copenhagen, Denmark))
      • 15:15 Dissecting quantitative epigenetic dynamics through mathematical modelling and experiments 45'
        Speaker: Martin Howard (("John Innes" Centre, Norwich, UK))
      • 16:00 Coffee break 30'
      • 16:30 Short oral presentations (from the best Posters) 1h30'
  • Friday, 19 September 2014
    • 09:15 - 14:30
      • 09:15 Insights on the bacterial nucleoid structure from fast chromosome dynamics 45'
        Speaker: Pietro Cicuta ((University of Cambridge, UK))
      • 10:00 Coffee break 30'
      • 10:30 microRNA-based regulation: From the ceRNA hypothesis to system-level effects in post-transcriptional control 45'
        Speaker: Andrea De Martino ((University of Rome, Italy))
      • 11:15 TBA 45'
        Speaker: Ana Pombo ((Max-Delbrück-Zentrum, Berlin, Germany))
      • 12:00 Concluding remarks 15'
      • 12:30 Lunch 2h0'