Models for active matter have brought a new type of experiments in statistical physics where the source of nonequilibrium lies within the particles themselves or on their surface. In this talk, I will take the viewpoint of molecular simulations to study matching experiments on chemically-powered nanomotors: self-propulsion by symmetry-breaking, chemotaxis, sedimentation and anisotropic nanomotors. I will comment on the design of consistent microscopic models with respect to energy conservation, to chemical kinetic, and to thermal fluctuations. As a perspective, I will discuss enzyme nanomotors. On the one hand, they consist in elaborate catalytic devices with interesting thermodynamic properties and on the other hand they might inspire or serve as molecular scale machine for nano- and bio-technology in the coming years.