Molecular dynamics simulation running simultaneous molecular granularities drastically reduce computational costs, making the study of whole viruses available to desktop computers. I will illustrate the use of a coarse-grained force field for biomolecules to perform a set of simulations on Zika, Dengue, and other related viruses. Comparative analysis among five common viruses pinpoints a collective variable that shows similar behavior only in the 3-fold symmetry axis of the icosahedral structure and coincides with the binding site of broadly neutralizing antibodies for Zika and Dengue.
Noteworthy, this dynamical similarity is only conserved in the same symmetry region of phylogenetically close viruses, suggesting an Achilles heel for crossed  neutralization of similar viruses.