Abstract: With the last energy & luminosity upgrade at the LHC, relevant results on tttt and ttbb are becoming available at the LHC for the first time. We'll analyze available results - which have moderate excesses - and discuss on possible paths to follow in order to seek for possible NP that couples mainly to third generation of quarks.  We identify in parameter space the relevant and yet unexplored regions.  We propose a new kinematic observable for resonance search and study the phenomenological natural units as a shortcut to understand and discuss the most sensitive channels to a given model.