Starts 13 May 2019 14:00
Ends 13 May 2019 15:00
Central European Time
ICTP
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A macroscopic theory for cellular states with steady-growth is presented, based on consistency between cellular growth and molecular replication, as well as robustness of phenotypes against perturbations. Adaptive changes in high-dimensional phenotypes are shown to be restricted within a low-dimensional slow manifold, from which a macroscopic law for cellular-states is derived, as is confirmed by adaptation experiments of bacteria under stress. Next, the theory is extended to phenotypic evolution, leading to proportionality between phenotypic responses against genetic evolution and by environmental adaptation.  Evolutionary relevance of slow modes in controlling high-dimensional phenotypes is discussed. Last, if I have time, transition from exponential-growth to stationary phases is investigated as the breakdown of steady-growth.  A general law between the starvation time and lag-time to recover the cellular growth is discussed.
 

References
 
  1.  Kaneko K., Life: An Introduction to Complex Systems Biology, Springer (2006)
  2.  K. Kaneko, C.Furusawa, T. Yomo, "Macroscopic phenomenology for cells in steady-growth state", Phys.Rev.X(2015) 011014
  3.  C. Furusawa, K. Kaneko "Global Relationships in Fluctuation and Response in Adaptive Evolution", J of Royal Society Interface 12(2015), 20150482.
  4.  C. Furusawa, K. Kaneko " Formation of Dominant Mode by Evolution in Biological Systems” Phys. Rev. E 97(2018)042410
  5.  K. Kaneko, C. Furusawa “Macroscopic Theory for Evolving Biological Systems Akin to Thermodynamics”, Annual Rev. Biophys. (2018) 47, 273-290
  6.  Y. Himeoka, K. Kaneko (2017). Theory for transitions between exponential and stationary phases: universal laws for lag time. Physical Review X,(2017) 7, 021049