Biological molecular motors are the enzymes which play crucial  roles in different cellular and developmental processes in a living cell.
 Helicases are molecular motors that unwind double-stranded nucleic acids  such as DNA and RNA. KIF1A is a single headed kinesin motor that takes part in intracellular transport along microtubule from cell center to cell  periphery.  They both perform mechanical work by hydrolyzing ATP.
In the flashing ratchet picture, the motor proteins switch between two  states: one where the motor is tightly bound to the track and another  where the motor is weakly bound and can diffuse along the track.  This  flashing ratchet mechanism can be found in these two motors.  In this talk I will discuss the speed of unwinding of the double stranded nucleic acid and fluctuations around the average unwinding velocity of the monomeric  helicase. Then I will emphasize the effects of mechanochemistry  and steric interactions on the KIF1A traffic.