Informal seminar on Statistical Physics: "Accelerated sampling of the conformational space in biomolecules: From small proteins to RNAs"
Starts 15 Jul 2011 17:00
Ends 15 Jul 2011 20:00
Central European Time
Leonardo da Vinci Building Luigi Stasi Seminar Room
Strada Costiera, 11
I - 34151 Trieste (Italy)
Recently developed free-energy methods (steered molecular dynamics, well-tempered metadynamics, parallel tempering and solute tempering) will be discussed, and their application to the folding of small proteins and RNA molecules will be shown. Using these techniques, a proposed model for RNA unwinding is validated and interpreted at atomistic resolution.