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Description New experimental techniques are opening windows on biological mechanisms inside the cell and in the brain, making these systems accessible to quantitative investigation.
These advances have shown the importance of the concerted interaction of many agents in producing overall behaviors, and call for an understanding of biological functions at the systemic level.
The present school responds to the need to provide physicists with a broad exposure to quantitative problems in the study of living systems.
The school is particularly targeted to young researchers, especially at the Ph.D and postdoc level who either work in this area or hope to do so.
Lectures by providing a broad overview of topics in Systems Biology, are planned by an array of distinguished lecturers. Research seminars associated with the school will also provide a venue for scientific exchange at the cutting edge 

Material

Winter School on Quantitative Systems Biology | (smr 2415)
Go to day
  • Monday, 26 November 2012
    • 08:10 - 09:00 Registration and Administrative Matters
      Location: Adriatico Guest House - Kastler Lecture Hall Area (Lower Level 1)
      • 08:10 Registration and Administrative Matters 50'
    • 09:00 - 09:30 Introduction, Student Presentation, Student Projects
      • 09:00 Introduction, Student Presentation, Student Projects 30'
    • 09:30 - 11:00 Introduction - Lessons from the problem of photon counting in vision
      • 09:30 Introduction - Lessons from the problem of photon counting in vision 1h30'
        Speaker: W. Bialek (Princeton University, USA)
    • 11:00 - 11:30 Coffee Break
      Location: Adriatico Guest House (Lower Level 1)
      • 11:00 Coffee Break 30'
    • 11:30 - 13:00 Modeling Biomolecular Networks
      • 11:30 Modeling Biomolecular Networks 1h30'
        Speaker: A. Sengupta (Rutgers, State Univ. of New Jersey, USA)
        Material: Course Material
    • 13:00 - 14:30 Lunch Break
      Location: Adriatico Guest House Cafeteria
      • 13:00 Lunch Break 1h30'
    • 14:30 - 16:00 Evolutionary dynamics: questions, numbers and simple models
      • 14:30 Evolutionary dynamics: questions, numbers and simple models 1h30'
        Speaker: D. Fisher (Stanford University, USA)
    • 19:00 - 21:00 Official Reception
      Location: Adriatico Guest House Cafeteria
      • 19:00 Official Reception 2h0'
  • Tuesday, 27 November 2012
    • 09:00 - 10:30 Information flow in biological networks
      • 09:00 Information flow in biological networks 1h30'
        Speaker: W. Bialek
    • 10:30 - 11:00 Coffee Break
      Location: Adriatico Guest House (Lower Level 1)
      • 10:30 Coffee Break 30'
    • 11:00 - 12:30 Modeling Biomolecular Networks Pt. 2
      • 11:00 Modeling Biomolecular Networks Pt. 2 1h30'
        Speaker: A. Sengupta
    • 12:30 - 14:00 Lunch Break
      Location: Adriatico Guest House Cafeteria
      • 12:30 Lunch Break 1h30'
    • 14:00 - 15:30 Evolution experiments and genotype-to-fitness maps
      • 14:00 Evolution experiments and genotype-to-fitness maps 1h30'
        Speaker: D. Fisher
    • 15:30 - 16:00 Coffee Break
      Location: Adriatico Guest House (Lower Level 1)
      • 15:30 Coffee Break 30'
    • 16:00 - 17:00 Participants Discussions
      • 16:00 Participants Discussions 1h0'
  • Wednesday, 28 November 2012
    • 09:00 - 10:30 Searching for collective behavior
      • 09:00 Searching for collective behavior 1h30'
        Speaker: W. Bialek
    • 10:30 - 11:00 Coffee Break
      Location: Adriatico Guest House Cafeteria
      • 10:30 Coffee Break 30'
    • 11:00 - 12:30 Modeling Biomolecular Networks Pt. 3
      • 11:00 Modeling Biomolecular Networks Pt. 3 1h30'
        Speaker: A. Sengupta
    • 12:30 - 14:00 Lunch Break
      Location: Adriatico Guest House Cafeteria
      • 12:30 Lunch Break 1h30'
    • 14:00 - 15:30 Recombination and complications
      • 14:00 Recombination and complications 1h30'
        Speaker: D. Fisher
    • 15:30 - 16:00 Coffee Break
      Location: Adriatico Guest House Cafeteria
      • 15:30 Coffee Break 30'
    • 16:00 - 17:00 Recent progress in understanding the neuronal population code in the retina
      • 16:00 Recent progress in understanding the neuronal population code in the retina 1h0'
        Speaker: G. Tkacik (Inst. of Science and Technology Austria, Klosterneuburg, Austria)
    • 20:30 - 22:00 Special Session
      • 20:30 Special Session 1h30'
  • Thursday, 29 November 2012
    • 09:00 - 10:30 An engineer's view of brain anatomy: an economically wired highly interconnected neural network
      • 09:00 An engineer's view of brain anatomy: an economically wired highly interconnected neural network 1h30'
        Speaker: M. Chkovskii (Howard Hughes Medical Institute, Virginia, USA)
        Material: lecture notes
    • 10:30 - 11:00 Coffee Break
      Location: Adriatico Guest House Cafeteria
      • 10:30 Coffee Break 30'
    • 11:00 - 12:30 Epigenetic Gene Regulation
      • 11:00 Epigenetic Gene Regulation 1h30'
        Speaker: J. Song (Univ. of California, San Francisco, USA)
        Material: lecture notes
    • 12:30 - 14:00 Lunch Break
      Location: Adriatico Guest House Cafeteria
      • 12:30 Lunch Break 1h30'
    • 14:00 - 15:30 Protein structure: principles, folding and predictions
      • 14:00 Protein structure: principles, folding and predictions 1h30'
        Speaker: R. Russell (Universitat Heidelberg, Germany)
    • 15:30 - 16:00 Coffee Break
      Location: Adriatico Guest House Cafeteria
      • 15:30 Coffee Break 30'
    • 16:00 - 17:00 Structure and dynamics of the large scale genetic regulatory networks of E. coli
      • 16:00 Structure and dynamics of the large scale genetic regulatory networks of E. coli 1h0'
        Speaker: S. Jain (University of Delhi, India)
  • Friday, 30 November 2012
    • 09:00 - 10:30 An engineer's view of early visual processing: De-noising and predictive coding in the retina and the LGN
      • 09:00 An engineer's view of early visual processing: De-noising and predictive coding in the retina and the LGN 1h30'
        Speaker: M. Chklovskii
        Material: lecture notes
    • 10:30 - 11:00 Coffee Break
      Location: Adriatico Guest House Cafeteria
      • 10:30 Coffee Break 30'
    • 11:00 - 12:30 Epigenetic Gene Regulation Pt.2
    • 12:30 - 14:00 Lunch Break
      Location: Adriatico Guest House Cafeteria
      • 12:30 Lunch Break 1h30'
    • 14:00 - 15:30 From structure to function
      • 14:00 From structure to function 1h30'
        Speaker: R. Russell
    • 15:30 - 16:00 Coffee Break
      Location: Adriatico Guest House Cafeteria
      • 15:30 Coffee Break 30'
    • 16:00 - 17:00 The Logic of Bacterial cell-to-cell communication
      • 16:00 The Logic of Bacterial cell-to-cell communication 1h0'
        Speaker: M. Thattai (Tata Inst. for Fundamental Research, Bangalore, India)
        Material: abstract
  • Saturday, 1 December 2012
    • 09:00 - 10:30 An engineer's view of neural computation: Hybrid digital/analog adaptive signal processing
      • 09:00 An engineer's view of neural computation: Hybrid digital/analog adaptive signal processing 1h30'
        Speaker: M. Chklovskii
    • 10:30 - 11:00 Coffee Break
      Location: Adriatico Guest House Cafeteria
      • 10:30 Coffee Break 30'
    • 11:00 - 12:30 Topics in Theoretical Neuroscience
      • 11:00 Topics in Theoretical Neuroscience 1h30'
        Speaker: V. Balasubramanian (University of Pennsylvania, Philadelphia, USA)
        Material: lecture notes
    • 12:30 - 14:00 Lunch Break
      Location: Adriatico Guest House Cafeteria
      • 12:30 Lunch Break 1h30'
    • 14:00 - 15:30 Macromolecular complexes and protein-protein interactions
      • 14:00 Macromolecular complexes and protein-protein interactions 1h30'
        Speaker: R. Russell
    • 15:30 - 16:00 Coffee Break
      Location: Adriatico Guest House Cafeteria
      • 15:30 Coffee Break 30'
    • 16:00 - 17:00 Population genetics in a cell: Mutation accumulation and Mitochondrial genome maintenance
      • 16:00 Population genetics in a cell: Mutation accumulation and Mitochondrial genome maintenance 1h0'
        Speaker: S. Goyal (University of California, Santa Barbara, USA)
  • Monday, 3 December 2012
    • 09:00 - 10:30 Statistical Physics Approaches to High-Dimensional Inference
      • 09:00 Statistical Physics Approaches to High-Dimensional Inference 1h30'
        Speaker: R. Monasson (Ecole Normale Superieure, Paris, France)
    • 10:30 - 11:00 Coffee Break
      Location: Adriatico Guest House (Lower Level 1)
      • 10:30 Coffee Break 30'
    • 11:00 - 12:30 Topics in Theoretical Neuroscience pt. 2
      • 11:00 Topics in Theoretical Neuroscience pt. 2 1h30'
        Speaker: V. Balasubramanian
        Material: lecture notes
    • 12:30 - 14:00 Lunch Break
      Location: Adriatico Guest House Cafeteria
      • 12:30 Lunch Break 1h30'
    • 14:00 - 15:30 Epigenetic Gene Regulation Pt. 3
    • 15:30 - 16:00 Coffee Break
      Location: Adriatico Guest House (Lower Level 1)
      • 15:30 Coffee Break 30'
    • 16:00 - 17:00 Phenotypic constraints drive the architecture of biological networks
      • 16:00 Phenotypic constraints drive the architecture of biological networks 1h0'
        Speaker: A. Samal (Institute for Systems Biology, Seattle, USA)
        Material: abstract lecture notes
  • Tuesday, 4 December 2012
    • 09:00 - 10:30 Topics in Theoretical Neuroscience Pt. 3
      • 09:00 Topics in Theoretical Neuroscience Pt. 3 1h30'
        Speaker: V. Balasubramanian
        Material: lecture notes
    • 10:30 - 11:00 Coffee Break
      Location: Adriatico Guest House (Lower Level 1)
      • 10:30 Coffee Break 30'
    • 11:00 - 12:30 Statistical Physics Approaches to High-Dimensional Inference Pt. 2
      • 11:00 Statistical Physics Approaches to High-Dimensional Inference Pt. 2 1h30'
        Speaker: R. Monasson
    • 12:30 - 14:00 Lunch Break
      Location: Adriatico Guest House Cafeteria
      • 12:30 Lunch Break 1h30'
    • 14:00 - 15:30 Relation of structure to function : molecular machines - motors and ion channels
      • 14:00 Relation of structure to function : molecular machines - motors and ion channels 1h30'
        Speaker: S. Doniach (Stanford University, USA)
        Material: lecture notes
    • 15:30 - 16:00 Coffee Break
      Location: Adriatico Guest House Cafeteria
      • 15:30 Coffee Break 30'
    • 16:00 - 17:00 Metabolic dynamics in microbial systems and ecosystems
      • 16:00 Metabolic dynamics in microbial systems and ecosystems 1h0'
        Speaker: D. Segre (Boston University, Boston, USA)
    • 19:30 - 21:30 Reception
      Location: Adriatico Guest House Cafeteria
      • 19:30 Reception 2h0'
  • Wednesday, 5 December 2012
    • 09:00 - 10:30 Statistical Physics Approaches to High-Dimensional Inference Pt 3
      • 09:00 Statistical Physics Approaches to High-Dimensional Inference Pt 3 1h30'
        Speaker: R. Monasson
    • 10:30 - 11:00 Coffee Break
      Location: Adriatico Guest House (Lower Level 1)
      • 10:30 Coffee Break 30'
    • 11:00 - 12:30 RNA folding : counter-ions, pseudo knotts and riboswitches
      • 11:00 RNA folding : counter-ions, pseudo knotts and riboswitches 1h30'
        Speaker: S. Doniach
        Material: lecture notes
    • 12:30 - 14:00 Lunch Break
      Location: Adriatico Guest House Cafeteria
      • 12:30 Lunch Break 1h30'
    • 14:00 - 15:30 The measure of a genome
      • 14:00 The measure of a genome 1h30'
        Speaker: R. Sachidanandam (Mount Sinai Sch. of Medicine, New York, USA)
        Material: lecture notes
    • 15:30 - 16:00 Coffee Break
      Location: Adriatico Guest House (Lower Level 1)
      • 15:30 Coffee Break 30'
    • 16:00 - 17:00 Student Work Time
      • 16:00 Student Work Time 1h0'
  • Thursday, 6 December 2012
    • 09:00 - 10:30 The Transcriptome: sequencing the effectors of the genome
      • 09:00 The Transcriptome: sequencing the effectors of the genome 1h30'
        Speaker: R. Sachidanandam
        Material: lecture notes
    • 10:30 - 11:00 Coffe Break
      Location: Adriatico Guest House (Lower Level 1)
      • 10:30 Coffe Break 30'
    • 11:00 - 12:30 Learning and memory: from bacteria to humans
      • 11:00 Learning and memory: from bacteria to humans 1h30'
        Speaker: S. Doniach
        Material: lecture notes
    • 12:30 - 14:00 Lunch Break
      Location: Adriatico Guest House Cafeteria
      • 12:30 Lunch Break 1h30'
    • 14:00 - 15:30 Of flies and men: Facets of biological systems
      • 14:00 Of flies and men: Facets of biological systems 1h30'
        Speaker: R. Sachidanandam
        Material: lecture notes
    • 15:30 - 16:00 Coffee Break
      Location: Adriatico Guest House (Lower Level 1)
      • 15:30 Coffee Break 30'
    • 16:00 - 17:00 Student Work Time
      • 16:00 Student Work Time 1h0'
  • Friday, 7 December 2012
    • 09:00 - 10:30 Student Presentations
      • 09:00 Student Presentations 1h30'
    • 10:30 - 11:00 Coffee Break
      Location: Adriatico Guest House (Lower Level 1)
      • 10:30 Coffee Break 30'
    • 11:00 - 12:30 Student Presentations
      • 11:00 Student Presentations 1h30'
    • 12:30 - 13:00 Conclusion and Final Remarks
      • 12:30 Conclusion and Final Remarks 30'
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